Many people are looking for methods to support their immune system in light of the current situation and growing interest in enhancing host defense and resilience.

The body is shielded from hazardous pathogens such as bacteria, viruses, protists, and parasites by a strong, robust immune system. On the other hand, a weakened immune system increases the chance of contracting an illness (as well as slower recovery and more severe outcomes following infection).

Many nutritional supplements, such as Vitamin C, Echinacea, and Elderberry, are frequently taken by people to support their immune systems.

Today, we take a closer look at Lion’s Mane, one of the “under the radar” supplements that is comparatively well-known but not necessarily for its immune-supporting qualities.


How Lion’s Mane Supports the Immune System

We’ve talked about lion’s mane previously, especially in relation to its potential advantages for brain health and cognitive performance.

It turns out that this odd-looking fungus, like other useful mushrooms like reishi, chaga, and turkey tail, may also help the immune system.

Lion’s mane may help the immune system by boosting intestinal immune system activity, according to animal studies (an important yet often overlooked component of the immune system). Pathogens that can reach the intestines through the mouth or nose may thus be less likely to cause disease as a result of this. [1]

Other studies have looked into the lion’s mane protein HEP3, which has immunomodulatory properties.

More precisely, tumor necrosis factor (TNF), interleukin (IL)-1, and IL-6 are only a few of the biomarkers that HEP3 may support. [2]

Furthermore, nuclear factor-B p65 and inducible nitric oxide synthase expression were shown to be downregulated.

In high-dose cyclophosphamide-induced immunotoxicity in mice, HEP3 may also strengthen the immune system by controlling the composition and metabolism of the gut microbiota to activate T cell proliferation and differentiation and stimulate intestinal antigen-presenting cells. [2]

Even after the overuse of antibiotics, research reveals that the proteins in lion’s mane mushrooms may function as prebiotics.


Last but not least, beta-glucan, a unique type of polysaccharide (carbohydrate) found in lion’s mane and other functional mushrooms, is well known for supporting a healthy immune response. [3]


Conclusion: Lion’s Mane Supports the Immune System

A mushroom called lion’s mane has been utilized in traditional medicine for thousands of years.

Although new study suggests it may help support the immune system, it is most frequently utilized for its potential advantages for brain health.

Initial studies on lion’s mane as an immune support supplement are quite intriguing, but more research is still needed.


Lion’s Mane Mushroom Gummies

You’re probably thinking how to effectively incorporate this amazing fungus into your life at this point. Although lion’s mane supplements come in the form of capsules, extracts, and powders, we choose gummies since they are practical, simple to consume, and mess-free.

Each Safer gummy is gluten-free, gelatin-free, vegan-friendly, and includes 100mg of lion’s mane per serving (standardized to contain 30% beta-glucans). Did we also mention how wonderful they are?

So go ahead and get up a bottle (or two) today and discover for yourself how lion’s mane can enhance the immune system.


Article Overview:

Lion’s Mane has been demonstrated to improve healthy immunity by boosting intestinal immune system function.

A unique kind of polysaccharide termed beta-glucan, which is widely known to support the activation of innate immune cells, is present in lion’s mane.

Try our vegan gummies, which contain 100mg of lion’s mane per serving, for a delightful and practical method to maintain the health of your immune system.



Sheng X, Yan J, Meng Y, Kang Y, Han Z, Tai G, Zhou Y, Cheng H. Food Funct. 2017 Mar 22;8(3):1020-1027. doi: 10.1039/c7fo00071e. PMID: 28266682.

Diling C, Chaoqun Z, Jian Y, Jian L, Jiyan S, Yizhen X, Guoxiao L. Front Immunol. 2017 Jun 12;8:666. doi: 10.3389/fimmu.2017.00666. PMID: 28713364; PMCID: PMC5492111.

SP Kim et al., Journal of Agricultural and FoodChemistry, vol. 60, no. 22